Intralipid: the new magic bullet in cardioprotection?

To the Editor: In two recent publications in Anesthesiology, Dr. Eghbali’s group reports the attenuation of myocardial reperfusion injury in rodents by intralipid administered on reperfusion.1,2 Taken together with another study by the same group in which intralipid prevents and even rescues pulmonary hypertension,3 and the serendipitous landmark discoveries of lipid rescue therapy against bupivacaineinduced cardiotoxicity first in dogs4 and then humans,5 intralipid appears to have become a new magic bullet for cardioprotection. Nevertheless, many questions remain. Li et al.2 state that intralipid acts through the phosphorylation of Akt/extracellular signal-regulated kinase-1/glycogen In Reply: We thank Drs. Johnson and Rice for correcting our inadvertent error from our article1 and agree with their comments.